ON DEMAND WEBINAR
On Demand: Comprehensive Blood Metabolomics Profiling of Parkinson’s Disease
Parkinson’s disease is characterized by a multitude of complexities, ranging from its heterogeneous clinical presentation to the intricate interplay of genetic, environmental, and neurobiological factors underlying its pathogenesis. While there are various therapies available to manage symptoms and improve the quality of life in Parkinson’s disease, the development of treatments capable of halting or reversing the underlying neurodegeneration remains an ongoing challenge.
Metabolomics research has emerged as a pivotal tool in unraveling the complexities of Parkinson’s disease (PD). By scrutinizing the intricate metabolic pathways within biological systems, metabolomics offers valuable insights into the biochemical alterations associated with PD onset and progression. This comprehensive approach enables researchers to identify potential biomarkers for early diagnosis, track disease progression, and evaluate treatment efficacy. Moreover, metabolomics facilitates a deeper understanding of the underlying mechanisms implicated in PD pathology, paving the way for the development of targeted therapeutic interventions. Through the integration of metabolomics data with other omics technologies and clinical findings, researchers can elucidate the intricate interplay between genetic predisposition, environmental factors, and metabolic dysregulation in PD pathogenesis. Ultimately, metabolomics research holds immense promise in revolutionizing our understanding of PD and advancing the development of personalized therapeutic strategies tailored to the unique metabolic profiles of individual patients.
You will learn:
- How comprehensive blood metabolomics profiling was used in the study of Parkinson’s disease (PD) by comparing treated and untreated patients with healthy controls.
- How bioinformatic analyses were used to uncover molecular mechanisms and significant metabolic alterations in PD.
- Benefits of targeted and untargeted metabolomics approaches
- The potential role of the enzyme hypoxanthine phosphoribosyltransferase 1 (HPRT1) as a key regulator of coordinated changes in xanthine metabolism.
Program
Achieving fast, accurate, and reproducible metabolomic data can be a challenging task that requires investing in people, technology, and novel methods to derive functional insights. In this short session, we demonstrate how Metabolon’s metabolomics-as-a-service solution can be leveraged to improve metabolite-level insights today.
- Examination of pronounced changes in xanthine metabolism in PD and their potential implications in the disease.
- Integrated analysis of metabolomics and transcriptomics data to identify potential key enzyme regulators of the metabolite changes observed in PD.
Assistant Professor in Bioinformatics and Deputy Course Director at the University of Luxembourg,
Business Development Director at Metabolon
