ON DEMAND WEBINAR

On Demand: Investigation of the Metabolomic Architecture of Obesity Implicates a “Mystery Metabolite” in Cardiometabolic Disease

Speaker: Dr. Nicholette D. Palmer, Ph.D.

Summary: In this presentation, Dr. Nicholette D. Palmer, Professor of Biochemistry at the Wake Forest School of Medicine, discusses her work identifying biomarkers for cardiometabolic disease.

Obesity is a major public health concern in the United States and data suggests that this problem will continue to get worse. Obesity is a complex health issue though as it is not only a risk factor for several comorbidities, but it is also drastically influenced by several external or exogenous factors.

Dr. Palmer’s work focuses on uses untargeted metabolomics approaches to understand the underlying mechanism of obesity and specifically its contributions to cardiometabolic disease risk in minority populations within the United States. She worked with the Insulin Resistance Atherosclerosis (IRAS) Family Study cohort which focused on individuals from three sites within the United States across rural and urban environments. Clinical, metabolomics, and genetics data were collected from these individuals to help determine patterns within the data. Watch the presentation to learn more about the correlations she found within her data, including the identification of a “mystery metabolite” and the method she used to identify it.

In this talk you will learn:

• • The importance of research into the mechanism of obesity and comorbidities
  • Methods for identifying unknown metabolites of significance within your dataset
  • Multiomic associations with cardiometabolic disease found from a population health study