ON DEMAND WEBINAR
Metabolomics: Novel Pathophysiological Insights in Pregnancies Affected by Type 1 Diabetes

Type 1 diabetes in pregnancy presents a unique set of challenges to ensure the well-being of both the mother and baby. Careful monitoring is required to maintain stable glucose levels to reduce the risk of complications. However, the mechanisms underlying the impact of glucose levels on the physiology of human pregnancy is not fully understood. Gaining insights into how pregnancy is affected by type 1 diabetes is vital for advancing care plans, reducing risk, and improving pregnancy outcomes.
Metabolomics, the study of small molecules, can help unveil intricate metabolic changes and decipher biomarkers associated with type 1 diabetes and pregnancy. This approach can facilitate a better understanding of this condition which can drive better care.
In this webinar, Claire Meek, Ph.D., a Professor of Chemical Pathology and Diabetes in Pregnancy at Leicester Diabetes Centre, discusses her work with the Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial (CONCEPTT). Dr. Meek outlines her methodology and approach to data analysis that enabled her to identify novel pathophysiological insights that can help to improve the care of pregnant individuals with type 1 diabetes.
In this webinar you will learn:
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- Implications and risks of type 1 diabetes during pregnancy
- How to utilize a metabolomics approach to understand underlying physiology
- Benefits of untargeted metabolomics approaches
- Strategies for metabolomics data analysis to provide actionable biological insights
Programme
Type 1 diabetes in pregnancy is associated with suboptimal pregnancy outcomes, attributed to maternal hyperglycemia and offspring hyperinsulinism. However, in-depth study of the physiology and pathophysiology of human pregnancy remains very challenging. We assessed metabolomic patterns associated with risk factors (maternal hyperglycemia, diet, BMI, weight gain) and perinatal complications (pre-eclampsia, large for gestational age, neonatal hypoglycemia, hyperinsulinism) in the Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial (CONCEPTT). Our findings highlighted novel pathophysiological processes with immediate implications for antenatal care.
This section of the webinar includes:
- A brief introduction to the main complications of type 1 diabetes in pregnancy
- A brief description of methodology
- A description of data analysis and approach to interpretation
Achieving fast, accurate, and reproducible metabolomic data can be a challenging task that requires investing in people, technology, and novel methods to derive functional insights. In this short session, we demonstrate how Metabolon’s metabolomics-as-a-service solution can be leveraged to improve metabolite-level insights today.
- Results of the metabolomics analysis
- A brief description of methodology
- Key translational implications for clinical care