Metabolon’s platform and services have contributed to over 3,000 publications. In May 2023, our data was used in 30 metabolomics citations. The application areas range from cardiovascular disease to agriculture.
The Metabolon Global Discovery Panel can detect and identify 5,400+ metabolites from serum, tissue, and fecal samples. With 20+ years of experience and an industry-leading library, Metabolon has the broadest coverage and capability to see potential biomarkers in your data.
Highlighted Publications
1. Multi-omics resources for targeted agronomic improvement of pigmented rice
Sedeek K, Zuccolo A, Fornasiero A, et al. Multi-omics resources for targeted agronomic improvement of pigmented rice. Nat Food. May 2023;4(5):366-371. doi:10.1038/s43016-023-00742-9
Pigmented rice is a rich source of nutrients, but pigmented rice lines typically have long life cycles and limited productivity. This research group used the Metabolon Global Discovery Panel to characterize the metabolites of 63 Asian rice varieties comprehensively. These data allowed the research group to identify rice varieties with superior nutrition for further genetic improvement. Metabolomics analysis revealed that Cempo Ireng is the most nutritious type of rice across all Asian rice varieties. Genome editing of Cempo Ireng resulted in an early maturing variety. This study provides a resource for understanding and improving Asian pigmented rice and human health.
2. Whole-genome sequencing analysis of human metabolome in multi-ethnic populations
Feofanova EV, Brown MR, Alkis T, et al. Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations. Nat Commun. May 30 2023;14(1):3111. doi:10.1038/s41467-023-38800-2
The metabolome reflects the state of human health and disease; therefore, the inclusion of ethnically diverse populations when studying the genetic architecture of metabolites is necessary. This research team performed whole-genome sequencing (WGS) and global metabolomics analysis using the Metabolon Global Discovery Panel in 11,840 multi-ethnic participants to elucidate novel genes associated with metabolites and health outcomes. They discovered 1,985 variant-metabolite associations and showed that the levels of 13 metabolites were related to the risk of 12 health outcomes, including type 2 diabetes. This study is the first WGS of the human metabolome in multi-ethnic populations, providing novel insights into understanding human disease.
3. Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers
Muhie S, Gautam A, Yang R, et al. Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers. Cell Rep Med. May 16 2023;4(5):101045. doi:10.1016/j.xcrm.2023.101045
Post-traumatic stress disorder (PTSD) affects more than 12% of war-zone-exposed veterans. In addition to emotional numbing and avoidance of reminders, PTSD can progress to systemic outcomes with comorbidities. This research group utilized a multi-omics approach to identify molecular alterations in response to PTSD in veterans and active-duty soldiers. The Metabolon Global Discovery Panel helped reveal molecular signatures of PTSD, including activated inflammation, oxidative stress, impaired angiogenesis, and metabolic dysregulation. These findings can help to address PTSD-related dysfunctions and may contribute to developing prevention and therapeutic treatments.
4. Respiratory virus-specific nasopharyngeal lipidome signatures and severity in infants with bronchiolitis: A prospective multicenter study
Kyo M, Zhu Z, Shibata R, et al. Respiratory virus-specific nasopharyngeal lipidome signatures and severity in infants with bronchiolitis: A prospective multicenter study. J Infect Dis. May 11 2023;doi:10.1093/infdis/jiad156
Bronchiolitis affects 40% of infants in the United States and its severity ranges from mild to fatal. Most bronchiolitis cases are caused by two viruses – respiratory syncytial virus (RSV) and rhinovirus (RV). Studies have shown that RSV infection leads to a longer hospital stay length than those with RV infection. Here, this research group used Metabolon’s Complex Lipids Targeted Panel to investigate the virus-specific lipidome signature and its relationship with bronchiolitis severity. Metabolon helped identify 30 discriminatory nasopharyngeal lipids and 8 fatty acids between RSV and RV infection. This study elucidates molecular differences in bronchiolitis severity and could lead to the development of a potential therapy for bronchiolitis.
5. Plasma levels of per-and polyfluoroalkyl substances (PFAS) are associated with altered levels of proteins previously linked to inflammation, metabolism and cardiovascular disease
Dunder L, Salihovic S, Lind PM, Elmståhl S, Lind L. Plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with altered levels of proteins previously linked to inflammation, metabolism and cardiovascular disease. Environ Int. May 24 2023;177:107979. doi:10.1016/j.envint.2023.107979
Per-and polyfluoroalkyl substances (PFAS) are a group of artificial chemicals with unique chemical properties widely used in industrial and consumer products, such as non-stick cookware and food packaging. The Metabolon Global Discovery Panel demonstrated that PFAS exposure is linked to altered levels of metabolites associated with inflammation, metabolism, and cardiovascular disease in middle-aged humans. This study provides mechanistic insights into the effects of PFAS on human disease.
Cardiovascular Disease
6. Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions
Kim H, Appel LJ, Lichtenstein AH, et al. Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions. Hypertension. May 10 2023;doi:10.1161/HYPERTENSIONAHA.123.20901
7. Retained Metabolic Flexibility of the Failing Human Heart
Watson WD, Green PG, Lewis AJM, et al. Retained Metabolic Flexibility of the Failing Human Heart. Circulation. May 18 2023;doi:10.1161/CIRCULATIONAHA.122.062166
8. Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension
Baranwal G, Goodlett BL, Arenaz CM, et al. Indole Propionic Acid Increases T Regulatory Cells and Decreases T Helper 17 Cells and Blood Pressure in Mice with Salt-Sensitive Hypertension. International Journal of Molecular Sciences. 2023; 24(11):9192. doi:10.3390/ijms24119192
9. Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling
Sun Y, Chanrasekhar V, Kessinger CW, et al. Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling. bioRxiv. 2023:2023.05.19.541546. doi:10.1101/2023.05.19.541546
10. Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease among Low-Income Black and White Americans
Deng K, Gupta DK, Shu X-O, et al. Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease among Low-Income Black and White Americans. medRxiv. 2023:2023.04.24.23289055. doi:10.1101/2023.04.24.23289055
11. Relationship between branched chain amino acids and type 2 diabetes: a bidirectional Mendelian Randomization study
Mosley JD, Shi M, Agamasu D, et al. Relationship between branched chain amino acids and type 2 diabetes: a bidirectional Mendelian Randomization study. medRxiv. 2023:2023.05.23.23290391. doi:10.1101/2023.05.23.23290391
12. Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP
Waldhart AN, Lau KH, Dykstra H, Avequin T, Wu N. Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP. iScience. May 19 2023;26(5):106538. doi:10.1016/j.isci.2023.106538
13. Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity
Lemmer IL, Haas DT, Willemsen N, et al. Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity. bioRxiv. 2023:2023.04.20.537611. doi:10.1101/2023.04.20.537611
14. Sex differences in associations of plasma metabolites with blood pressure and heart rate variability: The HELIUS study
Verhaar BJH, Mosterd CM, Collard D, et al. Sex differences in associations of plasma metabolites with blood pressure and heart rate variability: The HELIUS study. Atherosclerosis. May 28 2023;doi:10.1016/j.atherosclerosis.2023.05.016
15. Early Hyperlipidemia Triggers Metabolomic Reprogramming with Increased Sah, Increased Acetyl-Coa-Cholesterol Synthesis, and Decreased Glycolysis
Xu K, Saaoud F, Shao Y, et al. Early Hyperlipidemia Triggers Metabolomic Reprogramming with Increased Sah, Increased Acetyl-Coa-Cholesterol Synthesis, and Decreased Glycolysis. SSRN. May 15 2023; 10.2139/ssrn.4438950
Oncology
9. Novel metabolites to improve glomerular filtration rate estimation
16. An Individualized Prognostic Model in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma Based on Serum Metabolomic Profiling
Zhou J, Deng Y, Huang Y, et al. An Individualized Prognostic Model in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma Based on Serum Metabolomic Profiling. Life (Basel). May 11 2023;13(5).doi:10.3390/life13051167
17. Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway
10. Betaine and Soluble Fiber Improve Body Composition and Plasma Metabolites in Cats with Chronic Kidney Disease
Zhang J, Wang N, Zheng Y, et al. Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway. J Adv Res. May 2023;47:189-207. doi:10.1016/j.jare.2022.06.006
18. Lipidomics and pancreatic cancer risk in two prospective studies
Naudin S, Sampson JN, Moore SC, et al. Lipidomics and pancreatic cancer risk in two prospective studies. Eur J Epidemiol. May 12 2023;doi:10.1007/s10654-023-01014-3
Agriculture
19. Exposure to copper nanoparticles or copper sulfate dysregulated the hypothalamic-pituitary-gonadal axis, gonadal histology, and metabolites in Pelteobagrus fulvidraco
Zhao C, Chu P, Tang X, et al. Exposure to copper nanoparticles or copper sulfate dysregulated the hypothalamic-pituitary-gonadalaxis, gonadal histology, and metabolites in Pelteobagrus fulvidraco. J Hazard Mater. May 26 2023;457:131719. doi:10.1016/j.jhazmat.2023.131719
20. Lacticaseibacillus rhamnosus Strain GG (LGG) Regulate Gut Microbial Metabolites, an In Vitro Study Using Three Mature Human Gut Microbial Cultures in a Simulator of Human Intestinal Microbial Ecosystem (SHIME)
Liu L, Narrowe AB, Firrman JA, et al. Lacticaseibacillus rhamnosus Strain GG (LGG) Regulate Gut Microbial Metabolites, an In Vitro Study Using Three Mature Human Gut Microbial Cultures in a Simulator of Human Intestinal Microbial Ecosystem (SHIME). Foods. 2023; 12(11):2105. doi.org/10.3390/foods12112105
Precision Medicine
21. Omega-3 Fatty Acids Interact with DPP10 Region Genotype in Association with Childhood Atopy
Lee-Sarwar KA, Fischer-Rasmussen K, Bønnelykke K, et al. Omega-3 Fatty Acids Interact with Childhood Atopy. Nutrients. May 22 2023;15(10)doi:10.3390/nu15102416
22. MultiNEP: a Multi-omics Network Enhancement framework for Prioritizing disease genes and metabolites simultaneously
Xu Z, Marchionni L, Wang S. MultiNEP: a Multi-omics Network Enhancement framework for Prioritizing disease genes and metabolites simultaneously. Bioinformatics. May 22 2023;doi:10.1093/bioinformatics/btad333
23. Metabolomic Profile of Insulin Resistance Women with Systemic Lupus Erythe-matosus
Munguía-Realpozo P, Mendoza-Pinto C, Etchegaray-Morales I, et al. Metabolomic Profile of Insulin Resistance Women with Systemic Lupus Erythematosus. Horm Metab Res. May 13 2023;doi:10.1055/a-2093-0260
24. Low circulating valine associate with high risk of hip fractures
Grahnemo L, Eriksson AL, Nethander M, et al. Low circulating valine associate with high risk of hip fractures. J Clin Endocrinol Metab. May 13 2023;doi:10.1210/clinem/dgad268
Neuroscience
25. Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis
Virupakshaiah A, Ladakis DC, Nourbakhsh B, et al. Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis. Mult Scler. May 18 2023:13524585231171517. doi:10.1177/13524585231171517
26. 0449 Unbiased Examination of Metabolomic Signatures in Sleep Disordered Breathing and Group 1 PAH in the (PVDOMICS) Cohort
Ahmad I, Grunig G, Hemnes A, et al. 0449 Unbiased Examination of Metabolomic Signatures in Sleep Disordered Breathing and Group 1 PAH in the (PVDOMICS) Cohort. Sleep. 2023;46(Supplement_1):A199-A200. doi:10.1093/sleep/zsad077.0449
Other
27. HNF4α mediated QPRT expression in the kidney facilitates resilience against acute kidney injury
Clark AJ, Saade MC, Vemireddy V, et al. HNF4α mediated QPRT expression in the kidney facilitates resilience against acute kidney injury. bioRxiv. 2023:2023.05.23.541987. doi:10.1101/2023.05.23.541987
28. Metabolic disruption impacts tick fitness and microbial relationships
Samaddar S, O’Neal AJ, Marnin L, et al. Metabolic disruption impacts tick fitness and microbial relationships. bioRxiv. 2023:2023.05.26.542501. doi:10.1101/2023.05.26.542501
29. Infants Fed Breastmilk or 2′-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids
Hill DR, Buck RH. Infants Fed Breastmilk or 2′-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids. Nutrients. May 17 2023;15(10)doi:10.3390/nu15102339
30. Metabolomic analysis of small intestinal mucosa of SERT KO mice reveals alterations in microbial-related metabolites
Calzadilla N, Qazi A, Sharma A, et al. Metabolomic analysis of small intestinal mucosa of SERT KO mice reveals alterations in microbial-related metabolites. Physiology. 2023;38(S1):5730556. doi:10.1152/physiol.2023.38.S1.5730556
