Metabolon’s platform and services have contributed to over 3,000 publications. In March 2023, our data was used in 49 metabolomics citations. The market and therapeutic areas range from oncology to infectious diseases.
The Metabolon Global Discovery Panel can detect and identify 5,400+ metabolites from a wide variety of sample types, including serum, tissue, bacterial pellets, and fecal samples. With 20+ years of experience and an industry-leading library, Metabolon has the broadest coverage and capability to see potential biomarkers in your data.
Highlighted Publications
- Phenotypically driven subgroups of ASD display distinct metabolomic profiles
Prince N, Chu SH, Chen Y, et al. Phenotypically driven subgroups of ASD display distinct metabolomic profiles. Brain Behav Immun. Mar 31 2023;111:21-29. doi:10.1016/j.bbi.2023.03.026
Description: Autism spectrum disorder (ASD) is a neurodevelopmental disorder considered to be highly heterogeneous, meaning that there is significant variability in the severity and type of symptoms that individuals with ASD experience. This research group used the Metabolon Global Discovery Panel to investigate metabolic differences between ASD subgroups to gain biological insight into pathways associated with ASD traits. The study revealed that the subgroup of children with the highest degree of maladaptive behavior traits had an increased metabolism of membrane lipids and oxidative species. These pathways may represent important targets for personalized medicine approaches to manage ASD symptoms.
2. Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention
Watanabe K, Wilmanski T, Diener C, et al. Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention. Nat Med. Mar 20 2023;doi:10.1038/s41591-023-02248-0
Description: Obesity is a significant risk factor for several chronic diseases, such as diabetes and cardiovascular disease. This research group demonstrated that machine learning-based multiomic body mass index (BMI) estimates are better suited to assess the effectiveness of lifestyle interventions. The Metabolon Global Discovery Panel showed that plasma metabolomics exhibited the most robust response to lifestyle coaching than actual BMI. This study elucidates molecular perturbations associated with changes in obesity status, highlighting the usefulness of blood multiomic profiling for predictive and preventive medicine.
3. An atlas of genetic scores to predict multi-omic traits
Xu Y, Ritchie SC, Liang Y, et al. An atlas of genetic scores to predict multi-omic traits. Nature. Mar 29 2023;616(7955):123-131. doi:10.1038/s41586-023-05844-9
Description: Multiomic analysis is a powerful approach to understanding the underlying biology of diseases. This research group developed genetic scores for 17,227 multiomic traits across 5 platforms, including metabolomics, using the Metabolon Global Discovery Panel. They found that 379 metabolites could be genetically predicted. This study provides a key first step towards a better understanding of the distributions of therapeutically important biomarkers under high genetic control.
4. Community-specific diffusion characteristics determine resistance of biofilms to oxidative stress
Zhang Y, Cai Y, Chen Z. Community-specific diffusion characteristics determine resistance of biofilms to oxidative stress. Sci Adv. Mar 24 2023;9(12):eade2610. doi:10.1126/sciadv.ade2610
Description: Bacteria secrete a matrix of extracellular polymeric substances, which enable the formation of dense aggregates that are called biofilms. These scientists analyzed bacterial pellets using the Metabolon Global Discovery Panel to elucidate the responses of biofilm and bacteria to hydrogen peroxide (H2O2). Metabolomics demonstrated that under certain conditions, H2O2 boosted biofilm growth and that this mechanism occurs via a shift in energy metabolism. These results suggest that H2O2, which is commonly used as a disinfectant, is not suitable for biofilm sterilization and may accelerate the growth of biofilms and worsen infections.
5. Associations between per-and polyfluoroalkyl substances (PFAS) and diabetes in two population-based cohort studies from Sweden
Dunder L, Salihovic S, Elmståhl S, Lind PM, Lind L. Associations between per- and polyfluoroalkyl substances (PFAS) and diabetes in two population-based cohort studies from Sweden. J Expo Sci Environ Epidemiol. Mar 24 2023;doi:10.1038/s41370-023-00529-x
Description: Per-and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals with unique chemical properties that are widely used in industrial and consumer products, such as non-stick cookware and food packaging. Evidence of links between PFAS exposure and risk for developing diabetes is contradictory. The Metabolon Global Discovery Panel did not reveal any overall significant associations between the three investigated PFAS and prevalent diabetes. However, a significant inverse association was observed between PFAS levels and prevalent diabetes in women only.
Oncology
6. Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients-identification of patient subsets with increased transplant-related mortality
Reikvam PH, Bruserud P, Hatfield KJ. Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients – identification of patient subsets with increased transplant-related mortality. Transplant Cell Ther. Mar 24 2023;doi:10.1016/j.jtct.2023.03.020
7. Short-term starvation potentiates the efficacy of chemotherapy in triple-negative breast cancer via metabolic reprogramming
Pateras IS, Williams C, Gianniou DD, et al. Short-term starvation potentiates the efficacy of chemotherapy in triple-negative breast cancer via metabolic reprogramming. J Transl Med. Mar 03 2023;21(1):169. doi:10.1186/s12967-023-03935-9
8. Intermittent Fasting induced ketogenesis inhibits mouse epithelial ovarian tumors by promoting anti-tumor T cell response.
Udumula MP, Singh H, Faraz R, et al. Intermittent Fasting induced ketogenesis inhibits mouse epithelial ovarian tumors by promoting anti-tumor T cell response. bioRxiv. Mar 10 2023;doi:10.1101/2023.03.08.531740
9. Serum metabolomic profile of hair dye use
Lim JE, Huang J, Weinstein SJ, Parisi D, Mӓnnistö S, Albanes D. Serum metabolomic profile of hair dye use. Sci Rep. Mar 07 2023;13(1):3776. doi:10.1038/s41598-023-30590-3
Agriculture
10. Integrative transcriptomic and metabolomic analysis reveals alterations in energy metabolism and mitochondrial functionality in broiler chickens with wooden breast
Wang Z, Brannick E, Abasht B. Integrative transcriptomic and metabolomic analysis reveals alterations in energy metabolism and mitochondrial functionality in broiler chickens with wooden breast. Sci Rep. Mar 23 2023;13(1):4747. doi:10.1038/s41598-023-31429-7
11. Effect of environmental variance-based resilience selection on the gut metabolome of rabbits
Casto-Rebollo C, Argente MJ, García ML, Blasco A, Ibáñez-Escriche N. Effect of environmental variance-based resilience selection on the gut metabolome of rabbits. Genet Sel Evol. Mar 09 2023;55(1):15. doi:10.1186/s12711-023-00791-5
12. Exploring the mechanism of browning of Rosa roxburghii juice based on nontargeted metabolomics
Xu F, Zhu Y, Lu M, Zhao D, Qin L, Ren T. Exploring the mechanism of browning of Rosa roxburghii juice based on nontargeted metabolomics. J Food Sci. Mar 20 2023;doi:10.1111/1750-3841.16534
13. PIF4 promotes water use efficiency during fluctuating light and drought resistance in rice
Liu S, Essemine J, Liu Y, et al. PIF4 promotes water use efficiency during fluctuating light and drought resistance in rice. bioRxiv. Mar 3 2023; doi:10.1101/2023.03.02.530909
14. Divergent selection for IMF in rabbits: A story told by plasma metabolites
Zubiri-Gaitán A, Blasco A, Hernández P. Divergent selection for IMF in rabbits: A story told by plasma metabolites. Research Square. Mar 16 2023; doi:10.21203/rs.3.rs-2648510/v1
Infectious Diseases
15. Immunometabolic rewiring in long COVID patients with chronic headache
Foo SS, Chen W, Jung KL, et al. Immunometabolic rewiring in long COVID patients with chronic headache. bioRxiv. Mar 06 2023;doi:10.1101/2023.03.06.531302
16. A bile metabolite atlas reveals infection-triggered interorgan mediators of intestinal homeostasis and defense
Zhang T, Hasegawa Y, Waldor MK. A bile metabolite atlas reveals infection-triggered interorgan mediators of intestinal homeostasis and defense. bioRxiv. Mar 5 2023; doi:10.1101/2023.03.04.531105
17. Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels.
McDew-White M, Lee E, Premadasa LS, Alvarez X, Okeoma CM, Mohan M. Cannabinoids modulate the microbiota-gut-brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels. J Neuroinflammation. Mar 08 2023;20(1):62. doi:10.1186/s12974-023-02729-6
18. Muscle stem cells contribute to long‐term tissue repletion following surgical sepsis
Schmitt RE, Dasgupta A, Arneson-Wissink PC, Datta S, Ducharme AM, Doles JD. Muscle stem cells contribute to long-term tissue repletion following surgical sepsis. J Cachexia Sarcopenia Muscle. Mar 08 2023;doi:10.1002/jcsm.13214
Neuroscience
19. Untargeted metabolomics profiling in pediatric patients and adult populations indicates a connection between lipid imbalance and epilepsy
Oja KT, Ilisson M, Reinson K, et al. Untargeted metabolomics profiling in pediatric patients and adult populations indicates a connection between lipid imbalance and epilepsy. medRxiv. Mar 30 2023;doi:10.1101/2023.03.29.23287640
20. Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain
Lee H, Park J, Kim S. Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain. Metabolites. Mar 20
21. Deciphering the Polyglucosan Accumulation Present in Lafora Disease Using an Astrocytic Cellular Model
Moreno-Estellés M, Campos-Rodríguez Á, Rubio-Villena C, Kumarasinghe L, Garcia-Gimeno MA, Sanz P. Deciphering the Polyglucosan Accumulation Present in Lafora Disease Using an Astrocytic Cellular Model. Int J Mol Sci. Mar 23 2023;24(7)doi:10.3390/ijms24076020
22. Metabolic and Transcriptomic Changes in the Mouse Brain in Response to Short-Term High-Fat Metabolic Stress
Kim JK, Hong S, Park J, Kim S. Metabolic and Transcriptomic Changes in the Mouse Brain in Response to Short-Term High-Fat Metabolic Stress. Metabolites. Mar 09 2023;13(3)doi:10.3390/metabo13030407
23. Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance
Bernstock JD, Willis CM, Garcia-Segura ME, et al. Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance. bioRxiv. Mar 30 2023; doi:10.1101/2023.03.29.534718
24. Revealing the importance of prenatal gut microbiome in offspring neurodevelopment in humans
Sun Z, Lee-Sarwar K, Kelly RS, et al. Revealing the importance of prenatal gut microbiome in offspring neurodevelopment in humans. EBioMedicine. Mar 01 2023;90:104491. doi:10.1016/j.ebiom.2023.104491
25. Identification of plasma metabolites associated with modifiable risk factors and endophenotypes reflecting Alzheimer’s disease pathology
Dong R, Denier-Fields DN, Van Hulle CA, et al. Identification of plasma metabolites associated with modifiable risk factors and endophenotypes reflecting Alzheimer’s disease pathology. Eur J Epidemiol. Mar 25 2023;doi:10.1007/s10654-023-00988-4
26. Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice
Lum GR, Ha SM, Olson CA, et al. Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice. bioRxiv. Mar 22 2023; doi:10.1101/2023.03.17.533243
Renal And Urological Diseases
27. Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock
Bignon Y, Wigger L, Ansermet C, et al. Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock. J Clin Invest. Mar 02 2023;doi:10.1172/JCI167133
28. Association of the gut microbiome with kidney function and damage in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Peters BA, Qi Q, Usyk M, et al. Association of the gut microbiome with kidney function and damage in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Gut Microbes. Mar 07 2023;15(1):2186685. doi:10.1080/19490976.2023.2186685
29. NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury
Doke T, Mukherjee S, Mukhi D, et al. NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury. Nat Metab. Mar 13 2023;5(3):414-430. doi:10.1038/s42255-023-00761-7
Obesity
30. An integrated multi-omic approach demonstrates distinct molecular signatures between human obesity with and without metabolic complications: a case-control study
Mir FA, Mall R, Ullah E, et al. An integrated multi-omic approach demonstrates distinct molecular signatures between human obesity with and without metabolic complications: a case-control study. J Transl Med. Mar 29 2023;21(1):229. doi:10.1186/s12967-023-04074-x
31. Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery
Lappa D, Meijnikman AS, Krautkramer KA, et al. Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery. PLoS One. Mar 02 2023;18(3):e0279335. doi:10.1371/journal.pone.0279335
Cardiovascular Disease
32. Sex Differences in Fatty Acid Metabolism and Blood Pressure Response to Dietary Salt in Humans
Ishimwe JA, Ferguson JF, Kirabo A. Sex Differences in Fatty Acid Metabolism and Blood Pressure Response to Dietary Salt in Humans. Cardiogenetics. Mar 03 2023; 13(1):33 doi.org/10.3390/cardiogenetics13010005
33. Abstract P208: Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Trials
Kim H, Appel LJ, Lichtenstein AH, et al. Abstract P208: Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Trials. American Heart Association. Mar 14 2023; doi: 10.1161/circ.147.suppl_1.P208
34. Mid-Life Plasmalogens and Other Metabolites with Anti-Inflammatory Properties are Inversely Associated with Long term Cardiovascular Disease Events: Heart SCORE Study
Saeed A, McKennan C, Duan J, et al. Mid-Life Plasmalogens and Other Metabolites with Anti-Inflammatory Properties are Inversely Associated with Long term Cardiovascular Disease Events: Heart SCORE Study. medRxiv. Mar 05 2023. doi:10.1101/2023.03.02.23286731
35. Abstract P204: Associations Between Dairy Intake and Serum Metabolites in Middle-Aged Adults in the US
Bernard L, Chen J, Kim H, et al. Abstract P204: Associations Between Dairy Intake and Serum Metabolites in Middle-Aged Adults in the US. American Heart Association. Mar 14 2023; doi:1161/circ.147.suppl_1.P204
36. Metabolomics of Dietary Intake of Total, Animal, and Plant Protein: Results from the Atherosclerosis Risk in Communities (ARIC) Study1
Bernard L, Chen J, Kim H, et al. Metabolomics of Dietary Intake of Total, Animal, and Plant Protein: Results from the Atherosclerosis Risk in Communities (ARIC) Study. Current Developments in Nutrition. Mar 24 2023;7(4):100067. doi:10.1016/j.cdnut.2023.100067
Microbiome
37. Microbial community-scale metabolic modeling predicts personalized short-chain-fatty-acid production profiles in the human gut.
Bohmann N, Wilmanski T, Levy L, et al. Microbial community-scale metabolic modeling predicts personalized short-chain-fatty-acid production profiles in the human gut. bioRxiv. Mar 01 2023;doi:10.1101/2023.02.28.530516
38. Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Foley MH, Walker ME, Stewart AK, et al. Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut. Nat Microbiol. Mar 13 2023;8(4):611-628. doi:10.1038/s41564-023-01337-7
39. Faecal metabolome and its determinants in inflammatory bowel disease
Vich Vila A, Hu S, Andreu-Sánchez S, et al. Faecal metabolome and its determinants in inflammatory bowel disease. Gut. Mar 23 2023;doi:10.1136/gutjnl-2022-328048
Other
40. BZINB model-based pathway analysis and module identification facilitates integration of microbiome and metabolome data
Lin BM, Cho H, Liu C, et al. BZINB Model-Based Pathway Analysis and Module Identification Facilitates Integration of Microbiome and Metabolome Data.Microorganisms. Mar 16 2023;11(3)doi:10.3390/microorganisms11030766
41. A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis
Tsai CY, Saito T, Sarangdhar M, et al. A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis. Sci Transl Med. Mar 15 2023;15(687):eabn2110. doi:10.1126/scitranslmed.abn2110
42. Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress
Bedont JL, Kolesnik A, Pivarshev P, et al. Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress. Curr Biol. Mar 24 2023;doi:10.1016/j.cub.2023.03.008
43. Plasma concentrations of per-and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism
Prince N, Begum S, Mínguez-Alarcón L, et al. Plasma concentrations of per- and polyfluoroalkyl substances are associated with perturbations in lipid and amino acid metabolism. Chemosphere. Mar 4 2023;324:138228. doi:10.1016/j.chemosphere.2023.138228
44. Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice
Jamshidi N, Nigam KB, Nigam SK. Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice. Antioxidants (Basel). Mar 22 2023;12(3)doi:10.3390/antiox12030780
45. A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male
DeBalsi KL, Newman JH, Sommerville LJ, et al. A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male. Metabolites. Mar 08 2023;13(3)doi:10.3390/metabo13030399
46. Ligand-activation of the aryl hydrocarbon receptor up-regulates epidermal UDP-glucose ceramide glucosyltransferase and glucosylceramides
Sutter CH, Azim S, Wang A, et al. Ligand-activation of the aryl hydrocarbon receptor up-regulates epidermal UDP-glucose ceramide glucosyltransferase and glucosylceramides. J Invest Dermatol. Mar 31 2023;doi:10.1016/j.jid.2023.03.1662
47. Ketone monoester plus carbohydrate supplementation does not alter exogenous and plasma glucose oxidation or metabolic clearance rate during exercise in men compared with carbohydrate alone
Howard EE, Allen JT, Coleman JL, et al. Ketone Monoester Plus Carbohydrate Supplementation Does Not Alter Exogenous and Plasma Glucose Oxidation or Metabolic Clearance Rate During Exercise in Men Compared with Carbohydrate Alone. J Nutr. Mar 08 2023;doi:10.1016/j.tjnut.2023.03.002
48. Abstract P552: Mendelian Randomization Analysis of Metabolites Associated With Severe Obesity in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Young K, Buchanan VL, Graff M, et al. Abstract P552: Mendelian Randomization Analysis of Metabolites Associated With Severe Obesity in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). American Heart Association. Mar 14 2023; doi:10.1161/circ.147.suppl_1.P552
49. Fine particulate matter (PM2.5)-induced pulmonary oxidative stress contributes to changes in the plasma lipidome and liver transcriptome in mice
Kurlawala Z, Singh P, Hill BG, Haberzettl P. Fine Particulate Matter (PM2.5)-Induced Pulmonary Oxidative Stress Contributes to Changes in the Plasma Lipidome and Liver Transcriptome in Mice. Toxicol Sci. Mar 01 2023;doi:10.1093/toxsci/kfad020
