Metabolon’s platform and services have contributed to over 3,000 publications. In April 2023, our data was used in 26 metabolomics citations. The market and therapeutic areas range from oncology to nutrition.
The Metabolon Global Discovery Panel references a database of 5,400+ metabolites from serum, tissue, and fecal samples. Metabolon’s Bile Acids Targeted Panel measures the major human and rodent primary and secondary bile acids and their glycine and taurine conjugates. With 20+ years of experience and an industry-leading library, Metabolon has the broadest coverage and capability to see potential biomarkers in your data.
Highlighted Publications
1. Biomarkers of oxidative stress, diet, and exercise distinguish soldiers selected and non-selected for special forces training
Stein JA, Farina EK, Karl JP, et al. Biomarkers of oxidative stress, diet, and exercise distinguish soldiers selected and non-selected for special forces training. Metabolomics. Apr 11 2023;19(4):39. doi:10.1007/s11306-023-01998-9
Military personnel selected for special forces training exhibit distinct physical and psychological attributes compared to conventional service members. This research team used the Metabolon Global Discovery Panel to identify differences in the metabolomic profiles of selected and non-selected candidates. Metabolomics revealed that non-selected candidates exhibited higher levels of metabolites associated with oxidative stress. In contrast, candidates that were selected had high levels of metabolites associated with resistance to oxidative stress. This study highlights a comprehensive metabolomics approach to provide insight into the factors that distinguish soldiers selected and non-selected for special forces training.
2. A Metabolomics study of metabolites associated with the glomerular filtration rate
Peng H, Liu X, Ieong CA, et al. A Metabolomics study of metabolites associated with the glomerular filtration rate. BMC Nephrol. Apr 21 2023;24(1):105. doi:10.1186/s12882-023-03147-9
Chronic kidney disease (CKD) is a long-term condition characterized by the gradual loss of kidney function, leading to the accumulation of toxins in the body. Clinicians usually use glomerular filtration rate (GFR) to measure the kidneys’ function and efficiency in filtering waste products from the blood. It is considered one of the key indicators of kidney function. This research team exploited the Metabolon Global Discovery Panel to find novel biomarkers that can be used to determine GFR. Metabolomics of plasma samples from patients with different degrees of renal function identified potential biomarkers related to kidney health. These novel biomarkers may improve the estimation of GFR and provide potential therapeutic targets to improve kidney health.
3. Metabolomic profiling of glucose homeostasis in African Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS-FS)
Okut H, Lu Y, Palmer ND, et al. Metabolomic profiling of glucose homeostasis in African Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS-FS). Metabolomics. Apr 02 2023;19(4):35. doi:10.1007/s11306-023-01984-1
Diabetes type 2 is a chronic metabolic disorder characterized by elevated blood sugar levels due to insulin resistance. African Americans are at increased risk for type 2 diabetes. The authors utilized the Metabolon Global Discovery Panel to examine the metabolic signature of glucose homeostasis in African Americans. Metabolon helped reveal, for the first time, a differential ancestral effect of glutamate on glucose homeostasis, with significantly stronger effects observed in African Americans than in other populations. These findings demonstrate how metabolomics can be leveraged to study diabetes by race/ethnic background.
4. The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery
Louca P, Meijnikman AS, Nogal A, et al. The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery. Cell Rep Med. Apr 18 2023;4(4):100993. doi:10.1016/j.xcrm.2023.100993
Bariatric surgery is the most effective treatment for individuals with obesity, which elicits changes in metabolic health, appetite, and several comorbidities. This research group used Metabolon’s Bile Acids Targeted Panel to assess changes post-bariatric surgery and after nutritional interventions. The comprehensive analysis of serum and fecal bile acids showed that isoursodeoxycholate (isoUDCA) decreases significantly one year after bariatric surgery and in response to fiber supplementation. These data suggest that isoUDCA is a modifiable risk factor and elucidate the potential for modification of isoUDCA to achieve metabolic benefits through diet.
5. Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat
van Vliet S, Blair AD, Hite LM, et al. Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat. J Anim Sci Biotechnol. Apr 01 2023;14(1):49. doi:10.1186/s40104-023-00843-2
Bison meat is gaining popularity, so livestock producers are exploring ways to improve production systems. This research team used the Metabolon Global Discovery Panel to define the impact of two common finishing systems in bison: pasture-finished (grass-fed) or pen-finished. This study revealed that grass-fed bison have improved metabolic health and accumulate more potential health-promoting compounds in their meat than pen-fed bison. These findings show a link between animal metabolic health and nutrition.
Oncology
6. A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
Rhee J, Moore SC, Albanes D, et al. Abstract 4223: A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate. Cancer Research. 2023;83(7_Supplement):4223-4223. doi:10.1158/1538-7445.Am2023-4223
7. Metabolomic profiles of human glioma inform patient survival
Scott AJ, Correa LO, Edwards D, et al. Metabolomic profiles of human glioma inform patient survival. Antioxid Redox Signal. Feb 27 2023;doi:10.1089/ars.2022.0085
8. Urine metabolomic biomarkers discovery for bladder cancer diagnostics
Schwab AJ, Mitchell MW, Karoly ED, Sarangarajan R. Abstract 5546: Urine metabolomic biomarkers discovery for bladder cancer diagnostics. Cancer Research. 2023;83(7_Supplement):5546-5546. doi:10.1158/1538-7445.Am2023-5546
Renal Diseases
9. Novel metabolites to improve glomerular filtration rate estimation
Guo X, Peng H, Liu P, et al. Novel metabolites to improve glomerular filtration rate estimation. Kidney Blood Press Res. Apr 10 2023;doi:10.1159/000530209
10. Betaine and Soluble Fiber Improve Body Composition and Plasma Metabolites in Cats with Chronic Kidney Disease
Ephraim E, Jewell DE. Betaine and Soluble Fiber Improve Body Composition and Plasma Metabolites in Cats with Chronic Kidney Disease. FBE. 2023-06-19 2023;15(2)doi:10.31083/j.fbe1502008
Cardiovascular Health
11. Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity
Kankuri E, Finckenberg P, Leinonen J, et al. Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity. Exp Mol Med. Apr 03 2023;doi:10.1038/s12276-023-00967-5
12. Machine Learning Identifies Plasma Metabolites Associated With Heart Failure in Underrepresented Populations With the TTR V122I Variant
Park JK, Petrazzini BO, Saha A, et al. Machine Learning Identifies Plasma Metabolites Associated With Heart Failure in Underrepresented Populations With the TTR V122I Variant. Journal of the American Heart Association. Apr 2034. doi:10.1161/JAHA.122.027736
Nutrition
13. Metabolomics of Dietary Intake of Total, Animal, and Plant Protein: Results from the Atherosclerosis Risk in Communities (ARIC) Study
Bernard L, Chen J, Kim H, et al. Metabolomics of Dietary Intake of Total, Animal, and Plant Protein: Results from the Atherosclerosis Risk in Communities (ARIC) Study. Current Developments in Nutrition. Apr 2023;7(4):100067. doi:10.1016/j.cdnut.2023.10067
14. Integrated Microbiota and Metabolite Changes following Rice Bran Intake during Murine Inflammatory Colitis-Associated Colon Cancer and in Colorectal Cancer Survivors
Weber AM, Ibrahim H, Baxter BA, et al. Integrated Microbiota and Metabolite Changes following Rice Bran Intake during Murine Inflammatory Colitis-Associated Colon Cancer and in Colorectal Cancer Survivors. Cancers. 2023;15(8):2231. doi: 10.3390/cancers15082231
Neuroscience
15. Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment
Granot-Hershkovitz E, Spitzer B, Yang Y, et al. Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment. Transl Psychiatry. Apr 29 2023;13(1):140. doi:10.1038/s41398-023-02437-y
16. Multi-omic integration via similarity network fusion to detect molecular subtypes of ageing
Yang M, Matan-Lithwick S, Wang Y, De Jager PL, Bennett DA, Felsky D. Multi-omic integration via similarity network fusion to detect molecular subtypes of ageing. Brain Commun. 2023;5(2):fcad110. doi:10.1093/braincomms/fcad110
Liver Disease
17. Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients
Johanns M, Haas JT, Raverdy V, et al. Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients. bioRxiv. 2023:2023.04.05.535334. doi:10.1101/2023.04.05.535334
18. Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH
Szydlowska M, Lasky G, Oldham S, et al. Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH. Biochim Biophys Acta Mol Basis Dis. Apr 11 2023;1869(6):166697. doi:10.1016/j.bbadis.2023.166697
19. Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways
Faquih TO, van Klinken JB, Li-Gao R, et al. Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways. Liver Int. Apr 05 2023;doi:10.1111/liv.15575
Other
20. Clinical Untargeted Metabolomics as a Functional Screen to Improve Variant Classification
Gijavanekar C, Elsea SH. Clinical Untargeted Metabolomics as a Functional Screen to Improve Variant Classification. Curr Protoc. Apr 2023;3(4):e720. doi:10.1002/cpz1.720
21. Metabolic Reprogramming and Reliance in Human Skin Wound Healing
Manchanda M, Inuossa F, Torres M, et al. Metabolic reprogramming and reliance in human skin wound healing. J Invest Dermatol. Apr 13 2023;doi:10.1016/j.jid.2023.02.039
22. The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice
Zahid S, Dafre AL, Currais A, Yu J, Schubert D, Maher P. The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice. Int J Mol Sci. Apr 06 2023;24(7)doi:10.3390/ijms24076828
23. Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
de Wouters d’Oplinter A, Verce M, Huwart SJP, et al. Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward. Microbiome. Apr 28 2023;11(1):94. doi:10.1186/s40168-023-01526-w
24. Sphingomyelin d18: 1/14: 0 activates TLR4 in metaflammation
Latz E, Gorki F, Dohnalova L, et al. Sphingomyelin d18: 1/14: 0 activates TLR4 in metaflammation. Research Square. Apr 2023; doi: 10.21203/rs.3.rs-2792338/v1
25. Sex differences in body composition and serum metabolome responses to sustained, physical training suggest enhanced fat oxidation in women compared with men
Beckner ME, Thompson L, Radcliffe PN, et al. Sex differences in body composition and serum metabolome responses to sustained, physical training suggest enhanced fat oxidation in women compared with men. Physiol Genomics. Apr 03 2023;doi:10.1152/physiolgenomics.00180.2022
26. Exploring the association of physical activity with the plasma and urine metabolome in adolescents and young adults
Muli S, Brachem C, Alexy U, Schmid M, Oluwagbemigun K, Nöthlings U. Exploring the association of physical activity with the plasma and urine metabolome in adolescents and young adults. Nutr Metab (Lond). Apr 05 2023;20(1):23. doi:10.1186/s12986-023-00742-3
