Sebum Targeted Panel

Sebum is a complex mixture of lipids secreted by mature sebocytes onto the surface of the skin. Sebum may have antimicrobial, photoprotection, and vitamin delivery functions. Changes in the concentration and composition of sebum are related to acne and other skin disorders. Sebum is comprised of an unusual mix of lipid classes that is remarkably different in quantity and quality from lipids found in other organs. Major components are triglycerides, wax esters, squalene, and free fatty acids. The fatty acid composition of the complex lipids and the free fatty acid fraction is unique to human skin. Large amounts of the unusual sapienic acid (16:1n10), as well as a variety of odd and branched chain fatty acids, are present.

Metabolomics reveals biological insights otherwise unseen. For a successful metabolomics study, both small molecule discovery and the ability to dig deeper into specific biomarkers of interest are needed to uncover actionable insights that propel new therapeutic developments. A specific combination of gas or liquid chromatography-mass spectrometry (GC/MS or LC-MS) technology and biochemical expertise is required to identify these biomarkers of interest and develop assays that are sensitive enough to explore them fully.

At Metabolon, we understand the crucial role sebum plays in skin disorders, and we’ve established best-in-class expertise to identify and quantify its lipid components. This panel focuses on specific sebum lipids and their metabolic pathways and can be used to track biomarkers and enhance biological understanding across preclinical and clinical research.

Disclaimer: This method is for Research Use Only and is not to be used for diagnostic purposes.