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Metabolomics Connects Genome to Phenotype | Apr 2017

Metabolomics Connects Genome to Phenotype | Apr 2017

April 10, 2017

Understanding phenotypes is key to enabling research and medical advances. The exploration of gene function and the use of genomics tools have been a focal-point for unraveling phenotypes for the last two decades. But, while these genomic tools have provided many important insights and discoveries, a staggeringly complex picture has also emerged. Deciphering the meaningful biological signal from noise amongst all of this complexity is a persistent challenge.

Since metabolites are regarded as an intermediate phenotype, metabolomics has emerged as an ideal way to bridge the genotype-phenotype relationship. There are, however, critical considerations to successful implementation of metabolomics; platforms must be highly stable, scalable and able to capture a meaningfully broad swath of the metabolites within a biological sample.