Understanding Cancer Metabolism Through Global Metabolomics


Otto Warburg, is recognized as one of the key scientific generalists who was able to apply physical chemical data to better understand cancer cell metabolism. In the 1910s, he uncovered alterations in the intermediary metabolism of cancer cells that enabled cancer cell growth. His early discoveries led to the idea that cancer cells exhibited a reverse Pasteur effect of glycolysis in which glucose was rapidly metabolized to lactate. Thus, Warburg showed that the metabolism of cancer cells is fundamentally altered relative to normal cells. However, it has only been in the last 10 years that a number of investigators rediscovered that many oncogenes function through alterations in metabolism and that through this new metabolic understanding new cancer diagnostics and cancer treatments might be possible...


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